教育经历:
1996-1999，博士，东北师范大学电竞博彩平台电竞博彩网站
1993-1996，硕士，东北师范大学电竞博彩平台电竞博彩网站
1985-1989，学士，东北林业大学电竞博彩平台电竞博彩网站
工作经历:
2001 - 至今，电竞博彩网站-网上博彩网站讲师，副教授，教授
2006 - 2007，Visiting Scholar, DKFZ, 德国国家癌症中心
2002 - 2005，Postdoctoral fellow, University of Wisconsin at Madison，美国威斯康星大学麦迪逊分校生物化学系
1999 - 2001，博士后，电竞博彩网站-网上博彩网站细胞生物学专业荣誉奖励:
电竞博彩东宝奖教金 , 2015
北大第五届青年教师教学基本功演示竞赛三等奖 , 2009
教育部自然科学奖二等奖, 2007学术任职:
科技部国家重点研发计划项目首席科学家
电竞博彩伦理委员会委员
中国老年医学学会基础与转化医学分会委员
中国生物物理学会衰老分会理事
中国生理学会衰老与健康专业委员会委员执教课程:
细胞衰老与死亡（电子竞技博彩生）
电竞博彩平台原理与前沿（本科生）
衰老生物学（本科生）
细胞生物学（本科生） 我们主要运用单细胞组学、空间组学和代谢组学来电子竞技博彩癌化、衰老、消化系统相关以及神经退行性病变等人类相关疾病的机制和干预靶标。
关键科学问题：
1.电子竞技博彩衰老过程中表观遗传编程性变化的作用机制，筛选干预细胞和个体衰老的化学小分子；
2 电子竞技博彩人类相关疾病的动态变化规律，阐释这些动态变化的驱动因素，寻找干预靶点和手段；
本实验室招收生信专业或有相关背景的将毕业的本科和硕士生读博。
Ran Wei ,#, Zhehao Du # ,Jue Wang 2,3,4, # ,Jinlong Bi, Wencong Lyu, Haochen Wang, Jianuo He,Fanju Meng, Lijun Zhang, Chao Zhang*, Chen Zhang2,3,4 *, Wei Tao1*. A single-cell transcriptomic landscape characterizes the endocrine system aging in the mouse , 2025，Protein & Cell，2025，in print
Haochen Wang*, Wencong Lyu*, Yuzhe Sun*, Xinyi Jia*, Jinlong Bi, Ran Wei, Zhehao Du, Fanju Meng, Jianuo He, Shiyi Wang, Lijun Zhang, Chao Nie*, Wei Tao*, Heterochronic parabiosis alters the transcriptomic landscape to combat aging and aging-related diseases in aging-accelerated mice, Life Medicine, 2025，in print
Fanju Meng#, Jianuo He#, Xuebin Zhang#, Wencong Lyu#, Ran Wei, Shiyi Wang, Zhehao Du, Xiao-Li Tian, Lijun Zhang *, Wenbing Xie*, Wei Tao*. Histone lactylation antagonizes senescence and skeletal muscle aging by modulating aging-related pathways. Advanced Science，2025， e2412747
Lyu, W.#, Wang, H.#, Du, Z., Wei, R., Bi, J., He, J., Meng, F., Zhang, L., Zhang, C., Guan, Y.*, Tao, W.* Enalapril rescues aging by targeting antioxidant genes through phosphorylated Smad1/5/9. eLife，2025，14:RP104774
Min Yang,Jennie Ong,Fanju Meng,Feixiang Zhang,Hui Shen,Kerstin Kitt,Tengfei Liu,Wei Tao and Peng Du*. Spatiotemporal insight into early pregnancy governed by immune-featured stromal cells. Cell, 2023, in print
Zhou JT?, Zhang C?, Wei R?, Han M, Wang S, Yang K, Zhang L, Chen W, Wen MZ, Li C, Tao W* and Yuan YJ*. (2021). Exogenous artificial DNA forms chromatin structure with active transcription in yeast.Sci China Life Sci, 2022，65: 851–860
Xiaoke Huang?,Xuebin Zhang?,Le Zong，Qianqian Gao，Chao Zhang，Ran Wei,Yiting Guan,Li Huang,Lijun Zhang, Guoliang Lyv* and Wei Tao*.Gene body methylation safeguards ribosomal DNA transcription by preventing PHF6-mediated enrichment of repressive histone mark H4K20me3. Journal of Biological Chemistry, 2021，297(4) 101195
Bo He?, Chao Zhang?, Xiaoxue Zhang?, Yu Fan?, Hu Zeng, Jun`e Liu, Haowei Meng, Dongsheng Bai, Jinying Peng, Qian Zhang*, and Wei Tao* and Chengqi Yi*.Tissue-specific 5-hydroxymethylcytosine landscape of the human genome. Nature Communications,2021, 12: 0-4249
Chao Zhang?,Xuebin Zhang?,Li Huang,Yiting Guan,Xiaoke Huang,XiaoLi Tian,Lijun Zhang and Wei Tao*. ATF3 drives senescence by reconstructing accessible chromatin profiles. Aging Cell, 2021, 20(3): e13315
Yiting Guan?, Chao Zhang?, Guoliang Lyu, Xiaoke Huang, Xuebin Zhang, Tenghan Zhuang, Lumeng Jia, Lijun Zhang, Chen Zhang*, Cheng Li* and Wei Tao*. Senescence-activated enhancer landscape orchestrates the senescence-associated secretory phenotype in murine fibroblasts. Nucleic Acids Research, 2020, 48：10909–10923
Chao Zhang?, Zihan Xu?, shangda Yang?, Guohua Sun, Lumeng Jia, Lumeng Jia, Zhaofeng Zheng, Quan Gu, Wei Tao*, Hui Cheng*, Cheng Li* and Tao Cheng*. Chromatin architecture landscape in hematopoietic stem and progenitor cell populations. Cell Reports, 2020, 32：108206
Guoliang Lyu#, Yuting Guan# , Chao Zahng, Le Zong, Sun Lei, Xiaoke Huang. Li Huang, Lijun Zhang，Xiaoli Tian，Zhongjun Zhou and Wei Tao*.TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging. Nature Communications, 2018,Jul 2;9(1):2560
Meng Chen#, Guoliang Lyu#, Miao Han#, Hongbo Nie#, Ting Shen, Wei Chen, Yichi Niu, Yifan Song, Xueping Li, Huan Li, Xinyu Chen, Ziyue Wang, Zheng Xia, Wei Li, Xiao-Li Tian, Chen Ding, Jun Gu, Yufang Zheng, Xinhua Liu, Jinfeng Hu, Gang Wei*, Wei Tao*, Ting Ni.* 3′ UTR lengthening as a novel mechanism in regulating cellular senescence. Genome Research, 2018, 28: 285-294
Guoliang Lyu, Chao Zhang, Te Ling, Rui Liu, Le Zong, Yiting Guan, Xiaoke Huang, Lei Sun, Lijun Zhang, Cheng Li*, Yu Nie* and Wei Tao*. Genome and epigenome analysis of monozygotic twins discordant for congenital heart disease. BMC Genomics, 2018 19:428
Kai Liu, Lianggong Ding, Yuhong Li, Hui Yang, Chunyue Zhao, Ye Lei , Shuting Han, Wei Tao, Dengshun Miao, Hermann Steller, Michael Welsh* and Lei Liu*.Neuronal necrosis is regulated by a conserved chromatin-modifying cascade. PNAS. 2014,111:13960-65
Min Luo#, Te Ling#, WenbingXie#, He Sun, Yonggang Zhou, Qiaoyun Zhu, Meili Shen, Le Zong, Yun Zhao, Tao Ye, Jun Gu, Wei Tao*, Zhigang Lu*, Ingrid Grummt*. NuRD blocks reprogramming of mouse somatic cells into pluripotent stem cells. Stem Cells, 2013, 31:1278-86
Guoliang Lyu, Le Zong, Chao Zhang, Xiaoke Huang, Wenbing Xie, Junnan Fang, Yiting Guan, Lijun Zhang, Ting Ni#, Jun Gu#, Wei Tao# . Metastasis-related methyltransferase Merm1 represses the methyltransferase activity of Dnmt3a and facilitates RNA polymerase I transcriptional elongation. Journal of Molecular Cell Biology, 2019, 11(1), 78–90
Ling T, Xie W, Luo M, Shen M, Zhu Q, Zong L, Zhou T, Gu J, Lu Z, Zhang F, Tao W* , CHD4 maintains demethylation state of rDNA promoters through inhibiting the expression of the rDNA methyltransferase recruiter TIP5 , Biochem Biophys Res Commun, 2013, 19:101-107
Xie W, Ling T, Zhou Y, Feng W, Zhu Q, Stunnenberg HG, Grummt I*, Tao W* , The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions, PNAS, 2012, 109:8161-8166
Guanghliang LV, Tan Tan, Zong L, Yuting Guan， Lei Sun, Liang QJ* and Tao W*, Changes in the position and volume of inctive X Chromosomes during G0/G1 trnasition, Chromosome Research, 2018, 26：179-189
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